Selected Publications

Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase. Vergis N, Khamri W, Beale K, Sadiq F, Aletrari MO, Moore C, Atkinson SR, Bernsmeier C, Possamai LA, Petts G, Ryan JM, Abeles RD, James S, Foxton M, Hogan B, Foster GR, O'Brien AJ, Ma Y, Shawcross DL, Wendon JA, Antoniades CG, Thursz MR. Gut. 2016 Feb 9. pii: gutjnl-2015-310378. doi: 10.1136/gutjnl-2015-310378. [Epub ahead of print]

O'Brien AJ, Fullerton JN, Massey KA, Auld G, Sewell G, James S, Newson J, Karra E, Winstanley A, Alazawi W, Garcia-Martinez R, Cordoba J, Nicolaou A, Gilroy DW. Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.Nat Med. 2014 May;20(5):518-23. doi: 10.1038/nm.3516. Epub 2014 Apr 13

Antoniades H, Khamri W, Ma, Y, O'Brien A, Gilroy D, Vergani D, Mitry R, Starling C, Quaglia A, Heaton N, Heneghan M, Wendon J, & Thursz M. Secretory Leukocyte Protease Inhibitor (SLPI) is a pivotal mediator of anti-inflammatory responses in acute liver failure. Accepted by Hepatology 2013

Fullerton JN, O'Brien AJ, Gilroy DW. Lipid mediators in immune dysfunction after severe inflammation. Trends Immunol. 2014 Jan;35(1):12-21. doi: 10.1016/ Epub 2013 Nov 21

Fullerton, J. N., O'Brien, A. J. and Gilroy, D. W. Pathways mediating resolution of inflammation: when enough is too much. The Journal of Pathology 2013:231;8-20.

Alazawi W, Heath H, Waters JA, Woodfin A, O'Brien AJ, Scarzello AJ, Ma B, Lopez-Otalora Y, Jacobs M, Petts G, Goldin RD, Nourshargh S, Gamero AM, Foster GR. Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8656-61i

O'Brien AJ, Welch CA, Singer, M, Harrison DA.  Prevalence and outcome of cirrhosis patients admitted to UK intensive care. A comparison against dialysis-dependent chronic renal failure patients. Intensive Care Med. 2012; 38:991-1000.

O'Brien AJ, Williams R. Acute Liver Failure secondary to Wilson Disease; don't wait for the ceruloplasmin value, rather concentrate upon the readily available laboratory tests. Hepatology 2008; 48:1030-1032.

O'Brien AJ, Williams R. Nutrition in end-stage liver disease. Gastroenterology2008;134:1729-40.

Singer M, Coluzzi F, O'Brien AJ, & Clapp L.H. Reversal of life-threatening, drug related potassium-channel syndrome by glibenclamide. Lancet 2005; 365: 1873-5.

O'Brien AJ, Clapp LH, & Singer M. Terlipressin for norepinephrine-resistant septic shock. Lancet 2002; 359: 1209-10.